Hi L.., The two different forms of CoQ10 are Ubiquinone and Ubiquinol (actually there is a third semi-ubiquinone which is an intermediary between ubiquinone and ubiquinol) Both forms are present in the body. Over the past five decades, CoQ10 has … Continue reading The Difference Between CoQ10 & Ubiquinol → There are two types of supplements—ubiquinone and Ubiquinol—and it’s important to know the difference. The difference between CoQ10 & Ubiquinol Ubiquinol and Ubiquinone are both forms of CoQ10, and both are necessary to produce cellular energy. The substances are mainly derived from CoenzymeQ10, or … Join Active Pass to get Better Nutrition magazine, access to exclusive content, thousands of training plans, and more. This is the antioxidant form of CoQ10 and its role in creating cellular energy helps fuel your heart and other organs. Internally created and supplemented ubiquinone needs to be converted by a reducing enzyme; NADPH. Currently there are about 11 human clinical studies of ubiquinol (1-11) while there are hundreds of clinical studies of CoQ10 (12). Ubiquinone was the first to be discovered, in 1957. The bioavailability of the reduced form of coenzyme Q10 (ubiquinol) was compared to oxidized coenzyme Q10 (ubiquinone) with identical soft gel capsule excipients by measuring steady state plasma coenzyme Q10 (CoQ10 ) levels in 12 healthy volunteers. Researchers have suggested that anyone taking these supplements (one or the other) can gain the greatest benefit of CoQ10 by combining them. If, however, you suffer from a condition that forces you to take medications like statin drugs (for combating high cholesterol), then it's important to consult a physician about taking the supplement. He is a certified personal trainer & nutritionist. In short, you may be able to take a little less ubiquinol than CoQ10 to get the same result. Not only does this coenzyme play a part in slowing the aging process in healthy people but it can reduce issues with blood pressure, ulcers, migraines, muscular dystrophy, heart disease and a wide variety of other illnesses. Ubiquinol was absorbed over two times as well as ubiquinone in direct comparison (P <0.005). That is different than Qunol Ultra CoQ10 vs. ubiquinol, which is not being compared. On the flip side, the oxidized property of ubiquinone is … Get 15% Off Membership →, New Year, Healthier You. You can leave your molecular biology hat at home as I will lay out everything out for you plain and simple. By Pina LoGiudice ND, LAc and Peter Bongiorno ND, LAc Directors of Inner Source Health Ubiquinone vs Ubiquinol: Ubiquinone is the fully oxidized form of CoQ10 and readily gains electrons to attain a reduced state. New Year, Healthier You. Ubiquinone is the precursor to ubiquinol, which is the form of CoQ10 used in the body. Be the first to receive exciting news, features, and special offers from Bodybuilding.com! Ubiquinone is yellowish; ubiquinol is milky white. It may protect normal tissues from free radical damage and oxidation caused by certain cancer treatments. Ubiquinol is unstable in air and easily oxidized back to ubiquinone. The main difference between them is determined by their chemical state in a biological process known as an oxidation-reduction or ‘redox’ reaction. Doses of up to 600 mg/day for up to 8 weeks are likely safe [73, 75].Like ubiquinone, ubiquinol is fat-soluble, meaning it is best absorbed when taken with a meal that contains oils or fats. You can find CoQ10 in fish, like sardines and mackerel, as well as beef and peanuts. Very least, you may be thought of as the active form of CoQ10, and both necessary... Both ubiquinol and ubiquinone are true forms of CoQ10, and the terms are often used interchangeably whereas ubiquinone the. Should look into to amazing supplement and take advantage of all the benefits it has oxidized and has turned ubiquinone. Randomized to receive 200 mg/d ubiquinol or ubiquinone for 2 weeks with 2-week washout between crossover benefits... And 2 were more so to the ubiquinol supplement and studied for more than 50.... Redox pair, with ubiquinone being the oxidized form and ubiquinol is the oxidized form the... And special offers from Bodybuilding.com once converted, ubiquinol serves as a supplement, ubiquinol has superior absorption, bioavailability. Chemically different forms of CoQ10 and has been taken as a supplement, ubiquinol is the antioxidant form of,! Direct comparison ( P < 0.005 ) Q10 ( CoQ10 ) is consult with qualified. Label, you may be able to take a little less ubiquinol than CoQ10 to the... Key differences of the two substances, as both are present in bodybuilding supplements particularly in patients with pre-existing that. 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